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Nucleotide sequence of the human alpha-galactosidase A gene

R Kornreich1, R J Desnick, D F Bishop

  • 1Division of Medical and Molecular Genetics, Mount Sinai School of Medicine, New York, NY 10029.

Nucleic Acids Research
|April 25, 1989
PubMed
Abstract

No abstract available in PubMed .

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...

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