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Related Experiment Video

Updated: Apr 20, 2026

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
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Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

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CD34+ circulating progenitor cells after different training programs.

O Niño1, N Balague2, D Aragones2

  • 1Physiological Sciences II, L'Hospitalet de Llobregat, University of Barcelona, Spain.

International Journal of Sports Medicine
|November 28, 2014
PubMed
Summary
This summary is machine-generated.

Exercise training did not significantly alter circulating progenitor cell (CPC) levels in healthy males. However, baseline CPC counts inversely predicted post-training changes, indicating individual variability in response to physical activity.

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Area of Science:

  • Exercise Physiology
  • Hematopoiesis
  • Cell Biology

Background:

  • Circulating progenitor cells (CPCs) are crucial for tissue repair and hematopoiesis.
  • Exercise is known to influence hematopoiesis, but its effect on CPCs is debated.
  • Limited research compares different exercise modalities' impact on CPC concentrations.

Purpose of the Study:

  • To investigate the effects of aerobic, resistance, and mixed training on CPC CD34(+) concentrations.
  • To compare CPC responses across different training programs in healthy males.
  • To examine CPC levels pre-training, post-training, and during follow-up.

Main Methods:

  • 43 healthy males were divided into aerobic, resistance, mixed, and control groups.
  • Participants underwent 6 weeks of supervised training (except control).
  • Peripheral blood samples analyzed for CPC CD34(+) via flow cytometry at multiple time points.

Main Results:

  • No significant changes in CPC CD34(+) were found within or between training groups.
  • A trend towards increased CPCs post-training was observed, with high variability.
  • An inverse linear relationship existed between baseline CPCs and post-training percentage change.

Conclusions:

  • Six weeks of aerobic, resistance, or mixed training does not significantly alter CPC CD34(+) levels in healthy males.
  • Individual baseline CPC levels influence the magnitude of change in response to training.
  • Further research is needed to understand the complex relationship between exercise and CPC mobilization.