The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis

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Updated: Apr 20, 2026

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
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Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

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Yoshito Kakihara, Makio Saeki

    Biomolecular Concepts
    |November 28, 2014
    PubMed

    Insights

    The R2TP complex, crucial for cellular processes, is increasingly linked to cancer. This review explores its role in cell proliferation and carcinogenesis, proposing a link to tumorigenesis via snoRNA/snoRNP biogenesis regulation.

    Area of Science:

    • Molecular Biology
    • Cell Biology
    • Oncology

    Background:

    • The R2TP complex, initially identified in yeast, comprises Rvb1, Rvb2, Tah1, and Pih1.
    • This evolutionarily conserved eukaryotic complex participates in vital cellular functions including snoRNP biogenesis, RNA polymerase assembly, PIKK signaling, and apoptosis.

    Purpose of the Study:

    • To review recent research linking the R2TP complex to cell proliferation and carcinogenesis.
    • To propose a potential mechanism for R2TP's involvement in tumorigenesis through the regulation of snoRNA/snoRNP biogenesis.

    Main Methods:

    • Literature review of recent studies on the R2TP complex.
    • Analysis of the R2TP complex's role in cellular processes relevant to cancer.

    Main Results:

    • Emerging evidence suggests a connection between R2TP function and tumorigenesis.
    • The R2TP complex is implicated in regulating key cellular pathways.

    Conclusions:

    • The R2TP complex plays a significant role in cellular processes.
    • Dysregulation of R2TP may contribute to cancer development by affecting snoRNA/snoRNP biogenesis.

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