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Related Experiment Video

Updated: Apr 20, 2026

4D Multimodality Imaging of Citrobacter rodentium Infections in Mice
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Quarter-millimeter-resolution molecular mouse imaging with U-SPECT⁺.

Oleksandra Ivashchenko, Frans van der Have, Jose L Villena

    Molecular Imaging
    |November 29, 2014
    PubMed
    Summary

    The U-SPECT⁺ system achieves quarter-millimeter resolution for small animal molecular imaging. This advanced single-photon emission computed tomography (SPECT) enables unprecedented detail for preclinical research.

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    Area of Science:

    • Medical imaging
    • Preclinical research
    • Molecular imaging

    Background:

    • Preclinical positron emission tomography (PET) and single-photon emission computed tomography (SPECT) have limitations in spatial resolution.
    • This resolution bottleneck hinders the application of molecular imaging in small animal studies.

    Purpose of the Study:

    • To introduce the U-SPECT⁺ system, a next-generation radionuclide imaging platform.
    • To demonstrate its capability for high-resolution molecular imaging in mice.

    Main Methods:

    • Utilized the U-SPECT⁺ system with a 0.25 mm diameter circular pinhole collimator.
    • Calibrated the system using technetium-99m point source measurements.
    • Reconstructed images using pixel-based ordered subset expectation maximization (OSEM).

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    Main Results:

    • Achieved a reconstructed spatial resolution of 0.25 mm, visualizing structures like the femur epicondyle sulcus.
    • Demonstrated clear separation between cortical and trabecular bone in knee joint images.
    • Enabled measurement of tracer dynamics in small tissue volumes (0.015 μL) using time-activity curves.

    Conclusions:

    • The U-SPECT⁺ system offers superior spatial resolution compared to existing SPECT and PET systems.
    • This enhanced detail facilitates the replacement of ex vivo methods with in vivo monitoring.
    • Enables detailed in vivo monitoring of biological processes in small anatomical regions.