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Related Experiment Video

Updated: Apr 20, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Age-specific changes in left ventricular diastolic function: a velocity-encoded magnetic resonance imaging study.

Golmehr Ashrafpoor¹, Emilie Bollache, Alban Redheuil

¹Sorbonne Universités, UPMC Univ Paris 06, UMR 7371, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, 75013, Paris, France.

European Radiology

|November 29, 2014

Summary

Phase-contrast MRI (PC-MRI) provides reproducible age-related reference ranges for left ventricular diastolic parameters. These MRI findings can characterize sub-clinical age-related variations in healthy individuals, enhancing diagnostic value.

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Last Updated: Apr 20, 2026

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Published on: February 14, 2017

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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

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Published on: February 20, 2017

Area of Science:

Cardiovascular Imaging
Magnetic Resonance Imaging
Physiology

Background:

Echocardiography provides age-related reference ranges for left ventricular (LV) diastolic parameters, but similar data is lacking for cardiac MRI.
Assessing LV diastolic function is crucial for diagnosing various cardiac conditions.

Purpose of the Study:

To evaluate the capability of phase-contrast MRI (PC-MRI) in detecting sub-clinical age-related variations in LV diastolic parameters.
To establish age-related reference ranges for PC-MRI diastolic parameters.
To identify independent factors associated with these age-related variations.

Main Methods:

100 healthy volunteers underwent MRI with simultaneous blood pressure measurements.
LV mass and volumes were assessed.
Semiautomated PC-MRI analysis quantified early transmitral and atrial peak filling flow-rates and volumes, deceleration time, isovolumic relaxation time, and early myocardial longitudinal peak velocity.

Main Results:

PC-MRI diastolic parameters demonstrated high reproducibility.
Age was strongly and independently associated with peak myocardial velocity (E') and flow-rate parameters (p < 0.0001).
LV relaxation parameters were independently associated with LV remodeling and myocardial wall thickness (p < 0.01).

Conclusions:

Age-related reference ranges for LV diastolic parameters using PC-MRI are provided.
PC-MRI can reliably characterize sub-clinical age-related variations in diastolic function in healthy individuals.
Incorporating these diastolic parameters into clinical MRI exams can enhance diagnostic capabilities for conditions like cardiomyopathy and heart failure.