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Intradermal Inoculation of Mycobacterium avium in the Mouse Ear
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Variable agreement among experts regarding Mycobacterium avium complex lung disease.
Theodore K Marras1, D Rebecca Prevots, Frances B Jamieson
1Joint Division of Respirology, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Respirology (Carlton, Vic.)
|November 29, 2014
Summary
Clinical data for pulmonary Mycobacterium avium complex (pMAC) are scarce. Expert opinions vary widely, highlighting an urgent need for more research on pMAC diagnosis and treatment.
Area of Science:
- Pulmonology
- Infectious Diseases
- Mycobacterial Research
Background:
- Clinical data for pulmonary Mycobacterium avium complex (pMAC) are limited.
- Current guidelines for pMAC management heavily rely on expert opinion.
- Expert consensus is often achieved through variable weighting of individual opinions in meetings.
Discussion:
- A Delphi survey of North American non-tuberculous mycobacteria experts was conducted on pMAC clinical aspects.
- Seventy-three percent of invited experts responded, revealing significant variability in their opinions.
- Consensus was not reached on most survey questions, indicating widespread uncertainty.
Key Insights:
- Expert respondents expressed considerable uncertainty regarding various clinical issues in pMAC.
- The study highlights a significant lack of evidence-based data for pMAC management.
- Variability in expert opinion underscores the challenges in standardizing pMAC care.
Outlook:
- There is an urgent need for further research to address data gaps in pMAC.
- Future studies should focus on generating robust clinical evidence for pMAC.
- Developing standardized diagnostic and therapeutic approaches for pMAC requires more research.
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