Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

8.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.8K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

365
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
365
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

336
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
336
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.2K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

374
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
374
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

376
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
376

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heart Transplantation Requiring Permanent Pacemaker: Risk Factors and Outcomes.

Journal of clinical medicine·2026
Same author

Insurance Churn and Survival After Heart Transplantation, 2018-2024: A United States National Cohort Study.

Circulation. Population health and outcomes·2026
Same author

Epidemiology, clinical correlates, and management of focal periphyseal oedema (FOPE) in adolescent knees: retrospective analysis of one thousand, two hundred and one knees.

International orthopaedics·2026
Same author

How I Teach Mechanical Ventilator Waveform Analysis: A Focus on Normal Ventilator Waveforms.

ATS scholar·2026
Same author

Outcomes of Lung Transplantation From Asphyxiation Donors: Reassessing Hypoxic Injury and Implications for Donation After Circulatory Death.

Interdisciplinary cardiovascular and thoracic surgery·2026
Same author

Contemporary Outcomes of Heart Transplantation with Moderate to Severe Donor Left Ventricular Hypertrophy.

The Annals of thoracic surgery·2026

Related Experiment Video

Updated: Apr 20, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

13.4K

Plasma cell numbers decrease in bone marrow of old patients.

Theresa Pritz1, Julian Lair, Michael Ban

  • 1Institute for Biomedical Aging Research, Universität Innsbruck, Innsbruck, Austria.

European Journal of Immunology
|November 29, 2014
PubMed
Summary

Bone marrow plasma cells decrease with age in humans, impacting immune memory. This study analyzed age-related changes in bone marrow and blood B cells, revealing a decline in plasma and memory B cells.

Keywords:
AgingBone marrowMemory B cellsPlasma cells

More Related Videos

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

1.7K
Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

12.1K

Related Experiment Videos

Last Updated: Apr 20, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

13.4K
Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

1.7K
Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

12.1K

Area of Science:

  • Immunology
  • Aging Research
  • Cell Biology

Background:

  • The bone marrow (BM) is crucial for plasma cell survival in mice, but human BM plasma cell functions are less understood.
  • Aging impacts the immune system, affecting B cell populations and antibody production.

Purpose of the Study:

  • To investigate age-related changes in plasma cells and memory B cells in human bone marrow and peripheral blood.
  • To correlate antigen-specific B cell populations with antibody levels in aging individuals.

Main Methods:

  • Analysis of paired bone marrow biopsies and blood samples from individuals across different age groups.
  • Quantification of plasma cells, memory B cells, immature B cells, and naive B cells in both compartments.
  • Assessment of age-related changes in specific antibody titers and their correlation with B cell populations.

Main Results:

  • Plasma cells were predominantly found in the bone marrow, while memory B cells were more abundant in peripheral blood.
  • Frequencies of both plasma and memory B cells decreased with age, while immature and naive B cells remained unchanged.
  • An age-related decline was observed for tetanus- and diphtheria-specific BM plasma cells, but not for influenza A- or cytomegalovirus-specific ones.

Conclusions:

  • The human bone marrow harbors fewer plasma cells in older individuals.
  • The decline in specific plasma cells suggests an impact of aging on long-term immune memory, potentially influenced by past antigen exposure and BM microenvironment changes.