Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

9
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
9
Arboviral Encephalitis01:25

Arboviral Encephalitis

52
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
52
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

780
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
780
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

1.0K
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.0K
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

3
Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous...
3
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

907
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
907

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Impact of Plasticizer Polarity on the Permeability of Hydroxypropyl Methylcellulose Phthalate Films.

Molecular pharmaceutics·2026
Same author

Wild Edible Plants of Rosoideae Subfamily: Correlation of Phenolic Content with Bioactivity.

Molecules (Basel, Switzerland)·2026
Same author

The development of biologically contained Sudan virus as an alternative and safe tool for fundamental filovirus research.

Emerging microbes & infections·2026
Same author

Integrated omics reveal a unique antibacterial mechanism of action for the small molecule HSI#6.

Current research in microbial sciences·2026
Same author

Novel Dorsomorphin Derivatives: Molecular Modeling, Synthesis, and Bioactivity Evaluation.

Biomolecules·2026
Same author

Effect of the Bacterial Chaperones SecB and Trigger Factor (TF) on the Folding Dynamics and In Vitro Translocation of Cytoplasmic and Secretory Model Proteins.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Apr 20, 2026

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

900

Endothelial dysfunction in dengue virus pathology.

Peter Vervaeke1, Kurt Vermeire, Sandra Liekens

  • 1KU Leuven, Rega Institute for Medical Research, Leuven, Belgium.

Reviews in Medical Virology
|November 29, 2014
PubMed
Summary
This summary is machine-generated.

Dengue virus (DENV) infection impacts endothelial cells, crucial for blood vessel function. This review explores how DENV affects these cells, contributing to disease severity and vascular permeability.

More Related Videos

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.3K
Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

2.3K

Related Experiment Videos

Last Updated: Apr 20, 2026

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

900
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.3K
Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

2.3K

Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • Dengue virus (DENV) causes significant global illness, including severe dengue hemorrhagic fever and shock syndrome.
  • Pathogenesis of DENV remains incompletely understood, particularly the role of endothelial cells in disease progression.
  • Endothelial cells form the primary vascular barrier, yet their contribution to DENV pathology is debated.

Purpose of the Study:

  • To review the multifaceted effects of DENV infection on endothelial cell physiology.
  • To elucidate the direct and indirect mechanisms by which endothelial cells contribute to DENV pathogenesis.
  • To highlight the role of endothelial cell dysfunction in DENV-associated vascular permeability.

Main Methods:

  • Literature review of studies investigating DENV-endothelial cell interactions.
  • Analysis of research on DENV replication in endothelial cells.
  • Examination of evidence implicating viral proteins and antibodies in endothelial cell dysfunction.

Main Results:

  • DENV replicates in endothelial cells, challenging the notion of them being solely bystander cells.
  • DENV-infected endothelial cells contribute to viremia, immune activation, and vascular permeability.
  • Viral non-structural protein-1 and anti-DENV antibodies are implicated in endothelial cell dysfunction.

Conclusions:

  • Endothelial cells play a direct and significant role in DENV pathogenesis.
  • Understanding DENV's impact on endothelial cells is critical for developing effective treatments.
  • Further research is needed to fully characterize endothelial cell responses to DENV infection.