An allosteric receptor by simultaneous "casting" and "molding" in a dynamic combinatorial library.

Area of Science:

• Supramolecular Chemistry
• Systems Chemistry

Background:

• Designing allosteric synthetic receptors presents significant challenges.
• Allosteric systems are crucial for complex molecular interactions and functions.

Purpose of the Study:

• To develop a novel dynamic combinatorial strategy for accessing allosteric synthetic receptors.
• To investigate the formation and properties of termolecular complexes using a dual-template approach.

Main Methods:

• Employing a dynamic combinatorial chemistry approach.
• Utilizing simultaneous casting and molding techniques with two distinct templates.
• Analyzing the stepwise formation and cooperativity of the complex.

Main Results:

• A Russian-doll-like termolecular complex was successfully synthesized with remarkable selectivity.
• The binding of two partners to the central macrocycle demonstrated significant positive cooperativity.
• The strategy enables the controlled assembly of complex allosteric systems.

Conclusions:

• The reported dynamic combinatorial strategy offers an effective route to complex allosteric synthetic receptors.
• The observed positive cooperativity highlights the potential of these systems in advanced molecular recognition.
• These allosteric systems can serve as key hubs in the emerging field of systems chemistry.