Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

4.1K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
4.1K
Bone Disorders01:29

Bone Disorders

8.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.8K
Menopause01:28

Menopause

5.2K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.2K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

7.9K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
7.9K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.2K
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

3
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
3

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of the vitamin D metabolite ratio with bone turnover markers and changes in volumetric BMD.

JBMR plus·2026
Same author

Associations of Blood Biomarkers of Bone Turnover with Static Histomorphometry Parameters at the Hip in Patients with Chronic Kidney Disease Undergoing Surgery for Hip Fracture.

medRxiv : the preprint server for health sciences·2026
Same author

Association of radiomic features of skeletal muscle on CT images with muscle function and physical performance in older men.

Age and ageing·2026
Same author

The Osteoporotic Fractures in Men study (MrOS): a 25-yr landmark study of skeletal health in older men.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Leg Power and Velocity Predict the Risk of Major Osteoporotic Fractures (MOF): the Osteoporotic Fractures in Men (MrOS) Study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Exploratory survey study of differences in knowledge, attitudes, and practices of outpatient older adult clinical care between dermatologists, primary care physicians and geriatricians across three academic medical centers.

BMC geriatrics·2026
Same journal

Life-course metabolic vulnerability and chronic kidney disease risk after early-life famine exposure in Middle-aged and older chinese adults.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Global prevalence, trends, and dose-response associations of polypharmacy in older adults.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Global Burden and Temporal Prediction of Intestinal Obstruction (1990-2021) and the Relationship with Blood Metabolites: An Integrated Analysis of GBD and Mendelian Randomization.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Exercise Promotes Glutamate Transporter-Mediated Glutamate Uptake in the Striatum to Regulate MSN Plasticity and Alleviate Behavioral and Functional Impairments in PD Rats.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Adolescent Dietary Restriction Improves Cognition and Frailty in Aged Female Wistar Rats.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same journal

Frailty, polypharmacy, deprescribing and 23-hour activity: insights from a mouse model.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
See all related articles

Related Experiment Video

Updated: Apr 20, 2026

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

3.1K

Physical function in older men with hyperkyphosis.

Wendy B Katzman1, Stephanie L Harrison2, Howard A Fink3

  • 1Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco. wendy.katzman@ucsf.edu.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|November 29, 2014
PubMed
Summary
This summary is machine-generated.

Age-related hyperkyphosis is linked to poorer lower extremity physical function in older men. This study highlights the importance of spinal posture for mobility and health in aging males.

Keywords:
HyperkyphosisKyphosisNormative agingPhysical functionPhysical performance.

More Related Videos

Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

3.4K
Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis
07:44

Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis

Published on: March 23, 2019

19.0K

Related Experiment Videos

Last Updated: Apr 20, 2026

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

3.1K
Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

3.4K
Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis
07:44

Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis

Published on: March 23, 2019

19.0K

Area of Science:

  • Gerontology
  • Orthopedics
  • Physical Therapy

Background:

  • Age-related hyperkyphosis is a known predictor of adverse health outcomes in older women.
  • Its impact on health and physical function in older men remains less understood.

Purpose of the Study:

  • To evaluate the association between hyperkyphosis and physical function in a large cohort of older men.
  • To investigate the relationship between spinal curvature and measures of lower extremity function and grip strength.

Main Methods:

  • Cross-sectional study of 2,363 men (aged 71-98) from the Osteoporotic Fractures in Men Study.
  • Kyphosis measured using the Rancho Bernardo Study block method; physical function assessed via grip strength, gait speed, dynamic balance, chair stands, and lower extremity power.
  • Associations analyzed using age-adjusted and multivariable regression models, controlling for numerous covariates.

Main Results:

  • A dose-related response was observed: increased kyphosis (more blocks) correlated with worse lower extremity function (p for trend ≤.001).
  • Men with hyperkyphosis (≥4 blocks) showed 1.5-1.8 times higher odds of being in the worst quartile for lower extremity physical function tasks (p < .001).
  • No significant association was found between kyphosis and grip strength.

Conclusions:

  • Hyperkyphosis is significantly associated with impaired lower extremity physical function in older men.
  • These findings suggest spinal posture is an important factor in maintaining mobility in aging men.
  • Further research is warranted to establish the causal relationship between hyperkyphosis and physical function decline.