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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Long Non-Coding RNAs Involved in Immune Responses.

Katsutoshi Imamura1, Nobuyoshi Akimitsu1

  • 1Radioisotope Centre, The University of Tokyo , Tokyo , Japan.

Frontiers in Immunology
|November 29, 2014
PubMed
Summary

This review explores long non-coding RNAs (lncRNAs), which are over 200 nucleotides long. We summarize their crucial roles in regulating the complex human immune responses.

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NEAT1innate immune responselong non-coding RNA (lncRNA)translational repression

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Area of Science:

  • Molecular Biology
  • Immunology
  • Genetics

Background:

  • Non-coding RNAs (ncRNAs) are RNA transcripts that do not encode proteins.
  • ncRNAs are categorized into short and long classes based on length.
  • Long non-coding RNAs (lncRNAs) exceed 200 nucleotides and are involved in diverse biological processes.

Purpose of the Study:

  • To review and summarize the functions of lncRNAs.
  • To highlight the regulatory roles of lncRNAs in immune responses.

Main Methods:

  • Literature review of existing research on lncRNAs and immunity.

Main Results:

  • lncRNAs play significant roles in modulating various aspects of the immune system.
  • Specific lncRNAs have been identified that influence immune cell function and cytokine production.

Conclusions:

  • lncRNAs are critical regulators of immune responses.
  • Further research into lncRNA functions can offer new therapeutic strategies for immune-related diseases.