Related Experiment Video
Updated: Apr 20, 2026
06:09
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
9.7K
Melanoma arising after imiquimod use.
1University of Auckland, Auckland 1010, New Zealand ; University of Queensland, Brisbane, QLD 4072, Australia ; Skin Surgery Clinic, Auckland 0600, New Zealand.
Case Reports in Medicine
|November 29, 2014
Summary
Imiquimod is a topical cream used for skin cancer treatment. A rare case showed invasive melanoma developing at the application site, highlighting the need for careful patient monitoring.
Area of Science:
- Dermatology
- Oncology
- Pharmacology
Background:
- Imiquimod, a 1H-imidazo-[4,5-c]quinolone, was initially developed as an antiviral agent.
- It is a small, hydrophobic molecule suitable for topical formulations, effective against skin cancers like basal cell carcinoma and actinic keratosis.
- Imiquimod has also been used for cutaneous melanoma metastases and in situ melanoma.
Purpose of the Study:
- To report a case of invasive malignant melanoma arising at the site of Imiquimod application.
- To emphasize the importance of careful prescription and regular patient follow-up when using Imiquimod for skin cancer treatment.
Main Methods:
- Case report describing the development of invasive malignant melanoma.
- Review of literature on Imiquimod's use in skin cancer treatment.
Main Results:
- An invasive malignant melanoma developed de novo at the application site of Imiquimod (Aldara cream 5%) used for superficial basal cell carcinoma.
- This is a rare occurrence, contrasting with Imiquimod's established efficacy.
Conclusions:
- While Imiquimod is a valuable topical treatment for skin cancers, its use requires caution.
- Regular patient follow-up is crucial to monitor for any adverse events or secondary malignancies.
Related Concept Videos
01:30Skin Cancer
6.7K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.7K
01:19Pigmentation
5.1K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
5.1K
01:27Tumor Immunotherapy
2.6K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.6K