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Updated: Apr 20, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Pemphigoid gestationis in a third trimester pregnancy.
Senol Sentürk1, Nursel Dilek2, Yeşim Bayoğlu Tekin1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Recep Tayyip Erdoğan University, Merkez, Islampasa Mahallesi, Sehitler Caddesi, No. 74, 53100 Rize, Turkey.
Pemphigoid gestationis (PG) is a rare pregnancy skin condition. Early diagnosis and treatment of this autoimmune blistering disease can significantly improve patient outcomes.
Area of Science:
- Dermatology
- Immunology
- Obstetrics
Background:
- Pemphigoid gestationis (PG) is a rare autoimmune blistering disease during pregnancy.
- It typically manifests in the second or third trimester with intense itching and blisters.
- Accurate diagnosis and timely management are crucial for reducing maternal and fetal morbidity.
Purpose of the Study:
- To present a case of pemphigoid gestationis in a primigravida woman.
- To highlight the importance of recognizing this dermatosis for prompt intervention.
Main Methods:
- Clinical presentation review.
- Diagnostic confirmation via direct immunofluorescence studies of perilesional skin.
Main Results:
- A case of pemphigoid gestationis is described in a 33-year-old primigravida.
- The patient presented with generalized pruritus, a common initial symptom.
Conclusions:
- Pemphigoid gestationis requires prompt clinical suspicion and diagnostic workup.
- Effective management strategies can mitigate the adverse effects of this pregnancy-specific dermatosis.
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