Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

587
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
587
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

683
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
683
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

88
PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...
88
Drug Regulation01:25

Drug Regulation

3.4K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
3.4K
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

367
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
367
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

216
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
216

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Purpose in Life and Functional Reserve in a Memory Clinic Sample.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026
Same author

Screening for familial hypercholesterolemia in the era of artificial intelligence: A contemporary narrative review.

Journal of clinical lipidology·2026
Same author

Community Perceptions of Integrating Community Health Workers and Telehealth Services for Chronic Disease Management in a Rural Island Community: A Qualitative Study.

Journal of participatory medicine·2026
Same author

Inhaled Epoprostenol Augments Cold-Induced Vasodilation: A Double-Blind Crossover Trial.

Wilderness & environmental medicine·2025
Same author

Understanding the kidney replacement therapy decision-making process.

BMC nephrology·2025
Same author

ELSO 2025 Narrative Guideline on the Use of ECMO for Accidental Hypothermia.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2025

Related Experiment Video

Updated: Apr 20, 2026

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
08:09

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood

Published on: February 11, 2017

12.4K

Regulatory focus affects physician risk tolerance.

Peter J Veazie1, Scott McIntosh2, Benjamin P Chapman

  • 1Department of Public Health Sciences, University of Rochester.

Health Psychology Research
|November 29, 2014
PubMed
Summary
This summary is machine-generated.

Physician risk tolerance influences healthcare decisions. This study found that a promotion focus increased risk tolerance in primary care physicians more than a prevention focus, impacting practice variation.

Keywords:
Regulatory Focus Theorymedical decision makingprimary carerisk tolerance

More Related Videos

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.4K
Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

11.1K

Related Experiment Videos

Last Updated: Apr 20, 2026

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
08:09

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood

Published on: February 11, 2017

12.4K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.4K
Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

11.1K

Area of Science:

  • Medical Decision Making
  • Health Services Research
  • Psychology

Background:

  • Physician risk tolerance can lead to variations in clinical decision-making, potentially causing unnecessary healthcare utilization.
  • Identifying nonclinical factors influencing physician risk tolerance is crucial for addressing practice variations.
  • Regulatory Focus Theory suggests that an individual's focus (promotion or prevention) can influence their risk-taking behavior.

Purpose of the Study:

  • To investigate whether regulatory focus influences risk tolerance among primary care physicians.
  • To determine if situational regulatory focus is a nonclinical factor contributing to practice variations in healthcare.

Main Methods:

  • A randomized study involving 27 primary care physicians.
  • Physicians were assigned to either a promotion-focused or prevention-focused condition.
  • The Risk Taking Attitudes in Medical Decision Making scale was used to measure risk tolerance.

Main Results:

  • Physicians in the promotion-focus group exhibited significantly greater risk tolerance compared to those in the prevention-focus group (p = 0.01).
  • A large effect size (Cohen's d = 0.92) was observed, indicating a substantial difference.
  • Marginal evidence suggests an association between chronic regulatory focus and risk tolerance (p = 0.05).

Conclusions:

  • Situational regulatory focus significantly impacts physician risk tolerance, potentially explaining practice variations.
  • Interventions aimed at modifying physician risk tolerance should consider the influence of regulatory focus.
  • Further research is needed to clarify the mechanism linking chronic regulatory focus and risk tolerance.