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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Regulation of Expression Occurs at Multiple Steps02:24

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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[Long noncoding RNAs in gene expression control].

Yinghui Li1, Hui Fu

  • 1Department of Anatomy and Embryology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|November 30, 2014
PubMed
Summary
This summary is machine-generated.

Most of the mammalian genome transcribes into long noncoding RNAs (lncRNAs), which are key regulators of gene activity. These molecules play significant roles in biological development and disease, offering future clinical potential.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Biomedical Research

Background:

  • The mammalian genome extensively transcribes into long noncoding RNAs (lncRNAs).
  • lncRNAs are increasingly recognized for their critical roles in gene regulation.
  • Their involvement in development and disease is a rapidly growing area of research.

Purpose of the Study:

  • To summarize the multifaceted roles of lncRNAs in gene regulation.
  • To highlight the mechanisms by which lncRNAs exert their functions.
  • To underscore the significance of lncRNAs in biological processes and disease.

Main Methods:

  • Review of current literature on lncRNA functions.
  • Analysis of lncRNA mechanisms in gene expression control.
  • Synthesis of findings on lncRNAs in development and disease.

Main Results:

  • lncRNAs regulate gene expression through various mechanisms, including cis-/trans-action, mRNA stability, microRNA competition, and transcription factor binding.
  • These regulatory functions are crucial for normal development.
  • Dysregulation of lncRNAs is implicated in various diseases.

Conclusions:

  • lncRNAs are vital regulators of gene activity with diverse mechanisms.
  • Understanding lncRNA functions is essential for comprehending development and disease.
  • lncRNAs hold significant potential for future clinical applications in diagnostics and therapeutics.