[Genital Paget's disease].

¹Dept. of Dermatology, Saitama Medical School.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|April 1, 1989

Summary

This review of Paget's disease found that early-stage intraepidermal lesions have a 100% survival rate, while advanced stages with metastasis have a poor prognosis. Treatment varied by stage, with surgery for early stages and chemotherapy for advanced disease.

Area of Science:

Dermatology
Oncology

Context:

Paget's disease of the breast and nipple is a rare malignancy.
This study reviews genital and perianal Paget's disease cases over 30 years.

Purpose:

To analyze clinical characteristics, staging, treatment, and prognosis of genital and perianal Paget's disease.
To establish a staging system and evaluate treatment outcomes.

Summary:

A review of 72 cases (68 genital, 4 perianal) of Paget's disease, predominantly affecting males (2.8:1 ratio) aged 51-86.
A four-stage classification system was used, correlating with treatment and prognosis.
Stage I/II: wide local excision, skin graft; Stage III: radical node dissection added; Stage IV: immunochemotherapy.

Impact:

Early-stage Paget's disease (Stage I) shows a 100% 5-year survival rate.
Advanced stages (II-III) have reduced survival rates.
Stage IV disease has a 0% 3-year survival rate, highlighting the importance of early detection and treatment.

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