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The relationship between porosity and specific surface in human cortical bone is subject specific
C Lerebours1, C D L Thomas2, J G Clement2
1School of Mathematical Sciences, Monash University, VIC 3800, Australia; Northwest Academic Centre, University of Melbourne, VIC 3021, Australia.
Bone
|November 30, 2014
Summary
The relationship between bone volume fraction and specific surface in human cortical bone is subject-specific, not universal. Sex and pore density influence this relationship, challenging previous assumptions for bone microstructure.
Area of Science:
- Biomedical Engineering
- Orthopedic Research
- Materials Science
Background:
- A previously proposed bone intrinsic relationship between bone volume fraction (BV/TV) and specific surface (BS/TV) was based on 2D histology, with limited cortical bone data.
- This relationship's universality across bone types, sites, and health states is questioned due to limited cortical bone investigation.
Purpose of the Study:
- To investigate the BV/TV vs BS/TV relationship in human cortical bone using high-resolution micro-CT.
- To correlate this relationship with subject-specific biometric data (height, weight, age, sex).
Main Methods:
- Synchrotron radiation micro-CT imaging of femoral cortical bone samples from the Melbourne Femur Collection.
- Analysis of 16 bone samples from 13 individuals with bone volume fraction ranging from 0.20 to 1.
- Development of morphological models to explain the BV/TV vs BS/TV relationship.
Main Results:
- The BV/TV vs BS/TV relationship in cortical bone is subject-specific, not intrinsic.
- Sex and pore density showed statistical correlation with individual curves; height, weight, and age did not.
- Experimental cortical data deviated from previously proposed interpolating curves, particularly those based on trabecular bone.
Conclusions:
- The BV/TV vs BS/TV relationship is not universal and differs significantly between cortical and trabecular bone, even at similar porosities.
- Morphological models suggest BV/TV changes are driven by pore area increase, consistent with age-related bone loss.
- The relationship is non-linear at high BV/TV, approximating a square root function rather than a linear one.
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