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Post-operative nomogram for predicting freedom from recurrence after surgery in localised breast cancer receiving
Chafika Mazouni1, Frédéric Fina, Sylvie Romain
1Laboratoire de Transfert d'oncologie Biologique, Faculté de Médecine Nord, Assistance Publique - Hôpitaux de Marseille, Marseille, France, chafika.mazouni@gustaveroussy.fr.
Purpose:
To develop a prognostic nomogram to predict freedom from recurrence for patients treated with adjuvant hormonal therapy (HT) for localised breast cancer (BC).
Methods:
We performed a retrospective analysis of 142 patients treated with adjuvant HT between 1996 and 2000. Clinical and pathological parameters were analysed.
Results:
A nomogram that predicts the probability of remaining free of recurrence for 5 years after surgery with adjuvant HT was developed using a Cox proportional hazards regression model. The progesterone receptor status (p < 0.001), nodal status (p = 0.008) and cathepsin-D (p < 0.001) were retained to construct the nomogram (C-index 0.734).
Conclusions:
The nomogram we developed may be useful for estimating the probability of successful treatment 5 years after surgery for localised BC.
