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Antibiotic oxylipins from Alternanthera brasiliana and its endophytic bacteria
Marília Almeida Trapp1, Marco Kai2, Axel Mithöfer3
1LaBioMMi, Federal University of São Carlos, Rodovia Washington Luiz, km 235, CP 676, São Carlos - SP 13.565-905, Brazil; Department of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, Jena, Germany.
Abstract:
Bioassay-guided fractionation of Alternanthera brasiliana stem extracts resulted in the isolation of an antibiotically active fraction. Five human pathogenic bacteria were used to guide the fractionation process for the isolation of antimicrobial compounds. Finally, 17 linoleate oxylipins were identified by LC-MS/MS and NMR spectroscopy. Five of the isolated compounds present in A. brasiliana tissues were also detected to be synthesized by endophytic bacteria of the genus Bacillus that were isolated from A. brasiliana. It is speculated that the antibiotic oxylipins from A. brasiliana might derive from bacteria and be involved in an ecological relationship between this plant and its endophytes.
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