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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Updated: Apr 20, 2026

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
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Minimally invasive glaucoma surgery: current implants and future innovations.

Jeffrey R SooHoo1, Leonard K Seibold1, Nathan M Radcliffe2

  • 1Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colo.

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|December 1, 2014
PubMed
Summary

Minimally invasive glaucoma surgery (MIGS) offers a safer alternative to traditional glaucoma surgeries when medications fail. These procedures aim to lower intraocular pressure with fewer complications, improving patient outcomes.

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Area of Science:

  • Ophthalmology
  • Glaucoma Management
  • Surgical Innovation

Background:

  • Traditional glaucoma surgeries like trabeculectomy carry significant risks and failure rates.
  • Medication and laser trabeculoplasty may not adequately control intraocular pressure (IOP) in all glaucoma patients.
  • There is a need for safer surgical options to manage glaucoma effectively.

Purpose of the Study:

  • To define the characteristics of an ideal minimally invasive glaucoma surgery (MIGS) procedure.
  • To review current and investigational MIGS devices for glaucoma management.
  • To highlight the role of MIGS in bridging the gap between conservative therapy and traditional invasive surgery.

Main Methods:

  • Literature review of existing and emerging MIGS procedures.
  • Analysis of the safety and efficacy profiles of various MIGS techniques.
  • Discussion of ideal characteristics for MIGS implants.

Main Results:

  • MIGS procedures represent a new class of surgical interventions for glaucoma.
  • These procedures aim to reduce IOP with a lower complication rate compared to traditional surgeries.
  • New MIGS devices are continually being developed, expanding treatment options.

Conclusions:

  • MIGS offers a safer transition to surgical management for glaucoma patients.
  • The development of novel MIGS devices enhances treatment efficacy and safety.
  • MIGS procedures are crucial for managing glaucoma when conservative treatments are insufficient.