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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Published on: March 22, 2012

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[Invasive mould disease in haematological patients]

Isabel Ruiz-Camps1, Isidro Jarque2

  • 1Servicio de Enfermedades Infecciosas, Hospital Universitario Vall d'Hebron, Barcelona, España.

Revista Iberoamericana De Micologia
|December 2, 2014
PubMed

Insights

Invasive mould infections (IMI) pose a significant risk to patients undergoing chemotherapy or stem cell transplants. Risk assessment is crucial for selecting optimal antifungal strategies and improving survival rates.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Pharmacology

Background:

  • Invasive mould infections (IMI) present a critical challenge with high mortality in immunocompromised patients, particularly those with hematological malignancies and hematopoietic stem cell transplant (HSCT) recipients.
  • Managing IMI is complex due to evolving antifungal therapies and diagnostic tools, leading to diverse treatment strategies like prophylaxis, empirical, pre-emptive, and directed therapy.

Purpose of the Study:

  • To emphasize the critical role of individual risk assessment in optimizing prophylactic and therapeutic approaches for IMI.
  • To review current antifungal agents and selection criteria for hematologic patients.

Main Methods:

  • Literature review of current antifungal agents and treatment strategies for IMI in hematologic patients.
  • Discussion of risk stratification and selection criteria for antifungal therapy.

Main Results:

  • Commonly used antifungals include fluconazole, mould-active azoles (itraconazole, posaconazole, voriconazole), echinocandins (anidulafungin, caspofungin, micafungin), and lipid formulations of amphotericin B.
  • Individual risk assessment is vital for tailoring prophylactic and therapeutic interventions.

Conclusions:

  • Effective management of IMI in hematologic patients requires a personalized approach based on risk assessment.
  • Optimizing antifungal selection and strategy is key to improving patient survival rates.
Keywords:
Enfermedad fúngica invasoraFilamentous fungiHematological malignanciesHematopoietic stem cell transplantHongos filamentososInvasive fungal diseaseNeoplasias hematológicasTrasplante de progenitores hematopoyéticos

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