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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Coronary artery disease in giant cell arteritis: a systematic review and meta-analysis

Patompong Ungprasert1, Matthew J Koster1, Kenneth J Warrington1

  • 1Division of Rheumatology, Department of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

Seminars in Arthritis and Rheumatism
|December 2, 2014
PubMed

Insights

Giant cell arteritis (GCA) is a chronic inflammatory condition. This meta-analysis found no statistically significant increased risk of coronary artery disease (CAD) in patients with GCA compared to controls.

Area of Science:

  • Rheumatology
  • Cardiology
  • Epidemiology

Background:

  • Giant cell arteritis (GCA) is a systemic vasculitis affecting large arteries.
  • Chronic systemic inflammation is a known risk factor for cardiovascular diseases.
  • The relationship between GCA and coronary artery disease (CAD) risk requires clarification.

Purpose of the Study:

  • To systematically review and meta-analyze observational studies evaluating the association between GCA and the risk of developing CAD.
  • To quantify the pooled risk of CAD in individuals diagnosed with GCA.

Main Methods:

  • Systematic review and meta-analysis of observational studies.
  • Inclusion of studies reporting relative risks, hazard ratios, or standardized incidence ratios for CAD in GCA patients versus controls.
  • Calculation of pooled risk ratios and 95% confidence intervals using a random-effect model.

Main Results:

  • Six studies comprising 10,868 GCA patients and 245,323 controls were analyzed.
  • The pooled risk ratio for CAD in GCA patients was 1.51 (95% CI: 0.88-2.61), which was not statistically significant.
  • High statistical heterogeneity (I² = 97%) was observed across the included studies.

Conclusions:

  • This meta-analysis did not demonstrate a statistically significant increased risk of CAD in patients with GCA.
  • Unlike other chronic inflammatory conditions, GCA may not confer a heightened risk for CAD.
  • Further research may be warranted to explore potential confounding factors or specific subgroups.
Abstract

Keywords:
Coronary artery diseaseEpidemiologyGiant cell arteritisMeta-analysis

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