Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hand hygiene01:23

Hand hygiene

6.8K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
6.8K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

393
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
393
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

414
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
414
Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration01:23

Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration

124
Drug elimination from the body primarily occurs through metabolic and excretion pathways. Hepatic metabolism transforms lipophilic drugs into hydrophilic forms for excretion, typically via enzymatic processes classified as phase I (modification) and phase II (conjugation). Renal excretion eliminates drugs and metabolites through filtration and secretion in the kidneys. Impairment in liver or kidney function can hinder these processes, delaying drug clearance and extending the drug’s...
124
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

251
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
251
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

5.0K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formulation, Development, and Evaluation of Herbal Effervescent Mouthwash Tablet Containing <i>Azadirachta Indica</i> (Neem) and Curcumin for the Maintenance of Oral Hygiene.

Recent patents on drug delivery & formulation·2020
Same author

Ameliorative effect of curcumin on altered expression of CACNA1A and GABRD in the pathogenesis of FeCl<sub>3</sub>-induced epilepsy.

Molecular biology reports·2020
Same author

Echocardiographic assessment of hemodynamic changes in preterm neonates with shock: a prospective pragmatic cohort study.

European journal of pediatrics·2020
Same author

Plethysmography variability index (PVI) changes in preterm neonates with shock-an observational study.

European journal of pediatrics·2020
Same author

Viral Evolution will Automatically Resolve COVID-19 Pandemic.

Combinatorial chemistry & high throughput screening·2020
Same author

Letter by Sharma and Rasmussen Regarding Article, "Mechanical Thrombectomy in the Era of the COVID-19 Pandemic: Emergency Preparedness for Neuroscience Teams: A Guidance Statement From the Society of Vascular and Interventional Neurology".

Stroke·2020
Same journal

Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy in twin pregnancies: a systematic review and meta-analysis.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Clinical and immunological characteristics associated with adverse perinatal outcomes among pregnant people living with HIV: a retrospective cohort study.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Retraction statement: rupture of the pregnant uterus - a 20-year review.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Retraction statement: a new conservative surgical approach for placenta accreta spectrum in a low-resource setting.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Response to the letter regarding "cervical length and fetal fibronectin for the identification of true spontaneous onset of labor".

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Paternal age and adverse pregnancy outcomes: a spline analysis from the nulliparous pregnancy outcomes study: monitoring mothers-to-be study.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
See all related articles

Related Experiment Video

Updated: Apr 20, 2026

A Method to Test the Efficacy of Handwashing for the Removal of Emerging Infectious Pathogens
09:02

A Method to Test the Efficacy of Handwashing for the Removal of Emerging Infectious Pathogens

Published on: June 7, 2017

20.0K

Chlorhexidine - a novel intervention to decrease the nursery stay and antibiotic exposure duration - randomized

Deepak Sharma1, Geeta Gathwala2, Sweta Shastri3

  • 1a Department of Neonatology , Fernandez Hospital , Hyderabad , Andhra Pradesh , India .

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|December 2, 2014
PubMed
Summary
This summary is machine-generated.

Chlorhexidine (CHD) application to the umbilical cord significantly reduced newborn NICU stays and antibiotic exposure days. This simple intervention aids early discharge and combats antimicrobial resistance.

Keywords:
Chlorhexidineduration of antibiotics receivedduration of hospital stay

More Related Videos

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage
04:25

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

Published on: April 28, 2022

2.4K
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

1.4K

Related Experiment Videos

Last Updated: Apr 20, 2026

A Method to Test the Efficacy of Handwashing for the Removal of Emerging Infectious Pathogens
09:02

A Method to Test the Efficacy of Handwashing for the Removal of Emerging Infectious Pathogens

Published on: June 7, 2017

20.0K
A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage
04:25

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

Published on: April 28, 2022

2.4K
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

1.4K

Area of Science:

  • Neonatal care
  • Infectious disease prevention
  • Public health

Background:

  • Neonatal umbilical cord care is crucial for preventing infections.
  • Antibiotic overuse in neonatal intensive care units (NICUs) contributes to antimicrobial resistance.
  • Standard umbilical cord care may not be sufficient in all settings.

Purpose of the Study:

  • To evaluate the impact of chlorhexidine (CHD) umbilical cord application on NICU length of stay.
  • To assess the effect of CHD on antibiotic exposure duration in newborns.
  • To explore CHD as a strategy for reducing multidrug-resistant microbes.

Main Methods:

  • A randomized control trial involving 140 newborns (70 intervention, 70 control).
  • Intervention group received CHD spray on the umbilical cord thrice daily for three days post-birth.
  • Umbilical cord cultures, NICU stay duration, and antibiotic days were recorded.

Main Results:

  • The CHD group showed a significant reduction in NICU stay duration (12.4 days vs. 14.7 days, p=0.04).
  • Antibiotic exposure days were significantly lower in the CHD group (9.74 days vs. 12.1 days, p=0.04).
  • No mention of culture-proven sepsis rates in the provided abstract results.

Conclusions:

  • Topical chlorhexidine application to the umbilical cord effectively shortens NICU stays and reduces antibiotic exposure.
  • This intervention is a cost-effective strategy for improving neonatal outcomes, especially in resource-limited settings.
  • Widespread adoption of CHD could help mitigate the growing threat of multidrug-resistant organisms.