Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Therapies

Cancer Therapies

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Paediatric Therapeutic Development Workshop on rhabdomyosarcoma.

British journal of cancer·2026

Same author

A Bayesian-Based Integrative Bioinformatics Analysis Nominates Oncogenic Drivers in Neuroblastoma.

Clinical and translational science·2026

Same author

Trabectedin and low-dose irinotecan to target EWS::FLI1 in Ewing sarcoma: a phase 1/2 trial.

Nature medicine·2026

Same author

Resection of a Deep Pubic Alveolar Rhabdomyosarcoma With an Inferior Pubic Ramus Osteotomy Through a Perineal Approach: A Case Report.

Case reports in orthopedics·2026

Same author

Contemporary Management of Standard Chordoma Arising in the Mobile Spine and Sacrum.

The Journal of the American Academy of Orthopaedic Surgeons·2026

Same author

Factors Associated With Primary Site Local Therapy in Patients With Nonmetastatic Ewing Sarcoma Treated With Interval-Compressed Chemotherapy: A Report From the Children's Oncology Group.

International journal of radiation oncology, biology, physics·2025

Same journal

Barriers, Breakthroughs, and the Future of Pediatric Dermatologic Care.

Pediatric clinics of North America·2026

Same journal

Advancing Pediatric Dermatology: Innovations in Care and Access.

Pediatric clinics of North America·2026

Same journal

No Child Left Behind: Advancing Access in Pediatric Dermatology, a 4-Year, Single-Center Experience.

Pediatric clinics of North America·2026

Same journal

Telemedicine and Access to Pediatric Dermatology Care.

Pediatric clinics of North America·2026

Same journal

Inequitable Reimbursement for Pediatric Providers: A Review of Structural Factors that Disincentivize the Care of Children.

Pediatric clinics of North America·2026

Same journal

Medical Photography's Power to Change Medical Care.

Pediatric clinics of North America·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 20, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Sarcomas.

Josephine H HaDuong¹, Andrew A Martin², Stephen X Skapek²

¹Division of Hematology, Oncology, and Blood & Marrow Transplantation, Department of Pediatrics, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, 4650 Sunset Boulevard, MS 54, Los Angeles, CA 90027, USA.

Pediatric Clinics of North America

|December 2, 2014

Summary

This summary is machine-generated.

Childhood sarcomas, including bone and soft-tissue tumors, require multidisciplinary care. While localized disease has a 70-75% survival rate, metastatic or recurrent cases need better biological understanding for improved outcomes.

Keywords:

Bone Ewing’s Nonrhabdomyosarcoma Osteosarcoma Rhabdomyosarcoma Soft-tissue sarcoma

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Related Experiment Videos

Last Updated: Apr 20, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Area of Science:

Pediatric Oncology
Cancer Biology
Sarcoma Research

Background:

Childhood malignancies include approximately 14% bone and soft-tissue sarcomas.
Sarcomas encompass osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, and nonrhabdomyosarcoma.
Effective sarcoma treatment necessitates a multidisciplinary approach involving various medical specialties.

Purpose of the Study:

To summarize the current state of pediatric sarcoma treatment.
To highlight the need for improved understanding of sarcoma biology.
To underscore the challenges in treating metastatic or recurrent pediatric sarcomas.

Main Methods:

Review of current treatment modalities for pediatric sarcomas.
Analysis of survival rates for localized versus advanced disease.
Identification of knowledge gaps in sarcoma biology.

Main Results:

Localized pediatric sarcoma survival rates range from 70% to 75% with combined therapy.
Metastatic or recurrent pediatric sarcomas have poor outcomes.
Current understanding of sarcoma biology is insufficient for optimal treatment of advanced disease.

Conclusions:

Multidisciplinary care improves outcomes for localized pediatric sarcomas.
Further research into the underlying biology of bone and soft-tissue sarcomas is crucial.
Enhanced biological insights are required to improve survival for children with metastatic or recurrent sarcomas.