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Sirtuin modulators: an updated patent review (2012 - 2014)

Paolo Mellini1, Sergio Valente, Antonello Mai

  • 1Sapienza Università di Roma, Dipartimento di Chimica e Tecnologie del Farmaco , P.le A. Moro 5, 00185 Rome , Italy.

Expert Opinion on Therapeutic Patents
|December 2, 2014
PubMed
Abstract

Insights

Sirtuin research shows potential for treating aging-related diseases and neurodegeneration. While sirtuin inhibitors are explored for cancer, activators are key for metabolic and inflammatory disorders, with clinical trials underway.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Sirtuins (SIRT1-7) are crucial regulators of cellular metabolism, neuroprotection, apoptosis, inflammation, and cancer.
  • SIRT1 is a key target for aging-related diseases and caloric restriction.
  • SIRT modulation offers therapeutic potential for cancer, HIV, muscular diseases, and aging disorders.

Purpose of the Study:

  • To review patents on sirtuin modulation from 2012-2014.
  • To cover therapeutic applications of known and novel sirtuin modulators.
  • To explore sirtuin's role in various disease contexts.

Main Methods:

  • Patent literature review (2012-2014).
  • Analysis of sirtuin modulators and their therapeutic potential.
  • Examination of small molecules targeting sirtuin pathways.

Main Results:

  • Sirtuin's role in cancer remains controversial, with both tumor-promoter and suppressor properties observed.
  • Few SIRT inhibitors were patented between 2012-2014.
  • Sirtuin activators are under intense research for neurodegenerative diseases, metabolic disorders, and inflammation.

Conclusions:

  • Sirtuin activators show promise for treating neurodegenerative, metabolic, and inflammatory conditions.
  • Ongoing clinical trials for SIRT inhibitors and activators suggest future therapeutic applications.
  • Further research is needed to clarify sirtuin's complex role in disease.
Keywords:
diabetesepigeneticsinflammationobesitysirtuinssmall molecule activators

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