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Published on: August 24, 2015
A prospective study to determine the frequency of bacterial contamination of platelets
1Department of Pathology, Medical College (VIMS), Bellary, 583 104 Karnataka India.
Abstract:
Bacterial contamination of transfusion products is a long standing problem which includes donor bacteremia, contamination during the whole blood collection procedure, contamination of the collection pack and contamination during the blood processing procedure. The purpose of this study is to know the incidence of bacterial contamination of platelets and how to overcome it. During January 2009 to December 2010, 5,000 units of platelets concentrate were collected and 5 ml of platelet concentrate was sent for sterility test. A total of 8 units were reported as bacterially contaminated. Bacterial contamination can be reduced by better skin disinfection, collection of blood with a diversion pouch set, testing for bacteria and potentially the use of safe & effective pathogen reduction technologies and when available.
Insights
Bacterial contamination in platelet concentrates affects transfusion safety. This study found 8 out of 5,000 units contaminated, highlighting the need for improved collection and pathogen reduction strategies.
Area of Science:
- Transfusion Medicine
- Microbiology
- Blood Banking
Background:
- Bacterial contamination of blood products poses a significant risk to transfusion recipients.
- Sources of contamination include donor bacteremia, collection procedures, and processing.
- Platelets are particularly susceptible due to storage conditions.
Purpose of the Study:
- To determine the incidence of bacterial contamination in platelet concentrates.
- To identify strategies for reducing bacterial contamination in platelet products.
Main Methods:
- Analysis of 5,000 units of platelet concentrate collected between January 2009 and December 2010.
- Sterility testing performed on 5 ml aliquots from each unit.
Main Results:
- A total of 8 units (0.16%) were reported as bacterially contaminated.
- The incidence of contamination was found to be low but significant.
Conclusions:
- Bacterial contamination of platelet concentrates is a persistent challenge.
- Implementing enhanced skin disinfection, diversion pouch collection systems, and pathogen reduction technologies can mitigate risks.
