Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

10.2K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
10.2K
Mitochondria01:37

Mitochondria

21.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.7K
Epigenetic Regulation01:37

Epigenetic Regulation

4.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.3K
Epigenetic Regulation01:46

Epigenetic Regulation

34.6K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.6K
Epigenetic Regulation01:46

Epigenetic Regulation

26.8K
26.8K
Mitochondrial Membranes01:45

Mitochondrial Membranes

18.1K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
18.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The roles of TGFβ and serotonin signaling in regulation of germline progenitors in adult C. elegans hermaphrodites revealed by the effects of a male pheromone.

Developmental biology·2026
Same author

The roles of TGFβ and serotonin signaling in regulating proliferation of oocyte precursors and germline aging.

bioRxiv : the preprint server for biology·2024
Same author

A Caenorhabditis elegans Male Pheromone Feminizes Germline Gene Expression in Hermaphrodites and Imposes Life-History Costs.

Molecular biology and evolution·2023
Same author

Serotonergic signaling plays a deeply conserved role in improving oocyte quality.

Developmental biology·2023
Same author

A <i>C. elegans</i> male pheromone feminizes germline gene expression in hermaphrodites and imposes life-history costs.

bioRxiv : the preprint server for biology·2023
Same author

The serotonin circuit that coordinates germline proliferation and egg laying with other reproductive functions in <i>Caenorhabditis elegans</i>.

Proceedings. Biological sciences·2022

Related Experiment Video

Updated: Apr 20, 2026

Methodology for Accurate Detection of Mitochondrial DNA Methylation
12:11

Methodology for Accurate Detection of Mitochondrial DNA Methylation

Published on: May 20, 2018

14.1K

Progress in mitochondrial epigenetics.

Hari Manev, Svetlana Dzitoyeva

    Biomolecular Concepts
    |December 2, 2014
    PubMed
    Summary

    Mitochondria and epigenetics interact in four key ways, influencing gene expression and DNA methylation. A new term, mitoepigenetics, encompasses all these mitochondrial-epigenetic interactions.

    Area of Science:

    • Epigenetics
    • Mitochondrial Biology
    • Molecular Biology

    Background:

    • Mitochondria, organelles with their own DNA, interact with cellular epigenetic mechanisms.
    • Four distinct interaction pathways between mitochondria and epigenetics have been identified.
    • Existing research terms like 'mitochondrial epigenetics' require clarification.

    Purpose of the Study:

    • To review recent advancements in the field of mitochondrial-epigenetic interactions.
    • To propose a unifying term, 'mitoepigenetics', for all mitochondrial-epigenetic crosstalk.
    • To refine the definition and scope of 'mitochondrial epigenetics'.

    Main Methods:

    • Literature review of recent epigenetic research involving mitochondria.
    • Analysis of identified interaction mechanisms between mitochondrial and nuclear genomes.

    More Related Videos

    Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
    08:15

    Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs

    Published on: August 15, 2025

    1.3K
    Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
    07:24

    Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

    Published on: February 10, 2023

    2.1K

    Related Experiment Videos

    Last Updated: Apr 20, 2026

    Methodology for Accurate Detection of Mitochondrial DNA Methylation
    12:11

    Methodology for Accurate Detection of Mitochondrial DNA Methylation

    Published on: May 20, 2018

    14.1K
    Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
    08:15

    Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs

    Published on: August 15, 2025

    1.3K
    Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
    07:24

    Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

    Published on: February 10, 2023

    2.1K
  • Conceptual framework development for classifying mitochondrial-epigenetic interactions.

    • Main Results:

    • Mitochondria influence nuclear gene expression via nuclear-encoded mitochondrial genes.
    • Mitochondrial DNA content and activity impact nuclear gene methylation patterns.
    • Mitochondrial DNA variants affect nuclear gene expression and DNA methylation.
    • Mitochondrial DNA itself undergoes epigenetic modifications (e.g., methylation).

    Conclusions:

    • The relationship between mitochondria and epigenetics is multifaceted, involving bidirectional communication.
    • 'Mitoepigenetics' is proposed to encompass all four interaction types.
    • 'Mitochondrial epigenetics' should be reserved for intra-mitochondrial epigenetic modifications.