Pathogens: a new open access journal serving all those interested in infectious disease

Area of Science:

• Infectious Diseases
• Microbiology
• Public Health

Background:

• Infectious diseases are a major global cause of mortality, comparable to cardiovascular disease.
• In 2002, infectious diseases accounted for 26% of all deaths (nearly 15 million), with HIV/AIDS, TB, and malaria as primary culprits.
• Pediatric lower respiratory infections and diarrheal diseases contribute significantly to global infectious disease morbidity.

Purpose of the Study:

• To explore the historical development of understanding infectious agents and disease pathogenesis.
• To highlight how scientific advancements have led to effective disease control measures.
• To underscore the profound impact of infectious diseases on global health, agriculture, and economics.

Main Methods:

• Historical review of key discoveries in microbiology and epidemiology.
• Analysis of public health data on infectious disease mortality and morbidity.
• Examination of the evolution of prophylactic and therapeutic interventions.

Main Results:

• Early observations of microorganisms (e.g., bacteria by Van Leeuwenhoek) and epidemiological investigations (e.g., John Snow's cholera study) were pivotal.
• The acceptance of germ theory paved the way for rational disease control strategies.
• Development of vaccines (e.g., Pasteur's rabies and anthrax vaccines) and antibiotics revolutionized infection management.

Conclusions:

• Understanding the agents and mechanisms of infectious disease has been crucial for developing interventions.
• Scientific progress in microbiology and public health has led to significant reductions in infectious disease impact.
• Continued research into disease pathogenesis remains vital for combating global health threats.