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Updated: Feb 2, 2026

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
Hormones: electron emission, communication, mutual interaction, regeneration, metabolites, carcinogenesis and
Abstract:
Abstract This review discusses the highlights of the recently made discovery about the ability of hormones to eject 'solvated electrons' (eaq-) in water containing media. The resulting consequences for communication with other biological systems by the electron-transfer process, formation of metabolites, the possible initiation of cancer, hormone regeneration and the action of hormone-receptor systems are briefly discussed. The molecular structure of the hormones and the environment are hereby found to be the most important determining factors for the yield of ejected eaq-. Furthermore, the hormone transients, which result from emission of eaq-, are reviewed, as well as the formation of metabolites, which can be involved in various biological processes. The hormone-transients can also be regenerated by electron-transfer from a potent electron donor, at least partly, as long as they are in a 'status nascendi state'. The discussion of all these effects is supported by corresponding experimental data and experiments in vitro. This review presents a complete new conception of the action mechanisms of hormones.
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