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The Cancer Genomics Resource List 2014
Mary M Zutter, Kenneth J Bloom, Liang Cheng
1From the Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee (Dr Zutter); the Department of Pathology, Clarient Diagnostic Services, Aliso Viejo, California (Dr Bloom); the Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis (Dr Cheng); the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri (Drs Hagemann and Pfeifer); Surveys, College of American Pathologists, Northfield, Illinois (Dr Kaufman); the Department of Pathology, Emory University, Atlanta, Georgia (Dr Krasinskas); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Lazar); the Department of Pathology and Laboratory Medicine, Fletcher Allen Health Care, Burlington, Vermont (Dr Leonard); the Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the Department of Pathology, Mayo Clinic, Rochester, Minnesota (Dr Moyer); Molecular and Genomic Pathology Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Dr Nikiforova); the Department of Pathology, NorthShore University Health System, Evanston, Illinois (Dr Nowak); the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York (Dr Sepulveda); the Department of Pathology, Case Medical Center/Case Western Reserve University, Cleveland, Ohio (Dr Willis); and the Department of Molecular Pathology and Hematopathology, University of Minnesota, Minneapolis (Dr Yohe).
A new Cancer Genomics Resource List (CGRL) was developed to address variability in cancer genomic sequencing tests. The list compiles next-generation sequencing (NGS) panels and gene annotations to aid pathology and oncology professionals.
Area of Science:
- Oncology
- Genomics
- Molecular Diagnostics
Background:
- Genomic sequencing for cancer is offered by diverse entities, leading to significant test variability and a complex clinical environment.
- This variability complicates the selection and interpretation of genomic tests for cancer diagnosis and treatment.
Purpose of the Study:
- To address the complexity and confusion in cancer genomic testing, the College of American Pathologists' Personalized Health Care (PHC) Committee proposed the Cancer Genomics Resource List (CGRL).
- The CGRL aims to assist pathology and clinical oncology professionals by providing a standardized resource for cancer genomic tests.
Main Methods:
- A working group of cancer genetic sequencing experts was established in 2012.
- The group identified and compiled current next-generation sequencing (NGS)-based cancer tests, annotating genes using published knowledge, public databases, and medical literature.
Main Results:
- The Cancer Genomics Resource List (CGRL) 2014 includes NGS panels from 19 laboratories, covering 611 genes.
- Significant variability was observed: 0 genes were in every panel, 43 in 4 panels, 54 in 3 panels, and 393 genes were offered by only 1-2 institutions.
- An example of gene mutations for breast cancer genomic testing with CGRL annotations is provided.
Conclusions:
- The Cancer Genomics Resource List 2014 was finalized as a comprehensive resource for cancer genomic testing.
- The list is available as supplemental digital content for the pathology and clinical oncology communities.
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