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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
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Resolved P-metalated nucleoside phosphoramidites
Erica J Miller1, Kevin J Garcia, Erin C Holahan
1Department of Chemistry, Bucknell University , Lewisburg, Pennsylvania 17837, United States.
Inorganic Chemistry
|December 2, 2014
Abstract:
The synthesis of resolved P-metalated nucleoside phosphoramidites is described. These rare compounds were initially prepared with gold as the metal center; however, the gold can be removed using basic phosphines or solid-supported triphenylphosphine. Treatment of the free nucleoside phosphoramidite with a platinum source generated a unique platinated dinucleoside species with a diastereomeric ratio of >99:1.

