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Prevention of rheumatic diseases: strategies, caveats, and future directions
1Division of Rheumatology, University Hospital of Geneva, Rue Gabrielle-Perret-Gentil 4, Genève 1205, Switzerland.
Abstract:
Rheumatic diseases affect a significant portion of the population and lead to increased health care costs, disability, and premature mortality; effective preventive measures for these diseases could lead to substantial improvements in public health. Natural history studies show that for most rheumatic diseases there is a period of preclinical disease development during which abnormal biomarkers or other processes can be detected. These changes are useful to understand mechanisms of disease pathogenesis; in addition, they may be applied to estimate a personal risk of future disease while individuals are still relatively asymptomatic and ultimately be used to identify individuals who may be targeted for preventive interventions.
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