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Hypoglycemia with a large retroperitoneal mass - Case report.

Jennifer A Hawasli¹, Jacob R Hopping¹, Eddy C Hsueh¹

¹Department of Surgery, Saint Louis University School of Medicine, St. Louis, MO, United States.

International Journal of Surgery Case Reports

|December 2, 2014

Summary

A rare retroperitoneal sarcoma secreting insulin-growth factor II (IGF-II) caused hypoglycemia. Complete surgical resection of the tumor was the most effective treatment for this rare condition.

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Area of Science:

Oncology
Endocrinology
Surgical Pathology

Background:

Retroperitoneal sarcomas are rarely associated with insulin-growth factor II (IGF-II) secretion.
This secretion can lead to profound and enigmatic hypoglycemia.
IGF-II-secreting sarcomas are extremely rare soft tissue tumors.

Purpose of the Study:

To present a case of hypoglycemia caused by an IGF-II-secreting retroperitoneal sarcoma.
To describe the diagnosis and management of this rare syndrome.
To review the literature on IGF-II-secreting sarcomas and associated hypoglycemia.

Main Methods:

Case report of a patient with retroperitoneal sarcoma and hypoglycemia.
Successful treatment via complete surgical resection.

Keywords:

Hypoglycemia Insulin-like growth factor Retroperitoneal mass

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1-year follow-up and comprehensive literature review.

Main Results:

The patient's hypoglycemia was successfully treated by complete surgical resection of the retroperitoneal sarcoma.
The case highlights the diagnostic and management challenges of this rare condition.
Literature review confirms the rarity and clinical presentation of IGF-II-secreting sarcomas.

Conclusions:

Complete tumor resection plays a primary role in resolving tumor-induced hypoglycemia.
While steroid and growth hormone therapies may offer some efficacy, surgical intervention yields better outcomes.
This case and literature review underscore the importance of surgical management for IGF-II-secreting sarcomas causing hypoglycemia.