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Peripheral neuropathy associated with functional islet cell adenomas in SV40 transgenic mice
1Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
Abstract:
A line of SV40 transgenic mice (SV-202) developed a generalized peripheral neuropathy, islet cell adenomas of the pancreas, and hepatocellular carcinomas. The neuropathy was not directly associated with T-antigen expression in the nervous system. This study was designed to characterize the morphologic appearance and distribution of the neuropathologic lesions in SV-202 mice, and to relate the temporal development of peripheral nerve lesions to transgene-induced tumorigenesis in pancreatic islet cells. SV-202 mice developed an acute axonal degeneration that preferentially affected large diameter myelinated fibers. The onset of the neuropathy is closely correlated with the development of the hyperinsulinemia and hypoglycemia resulting from the islet cell adenomas.
Insights
SV40 transgenic mice (SV-202) developed peripheral neuropathy and tumors. The neuropathy, an acute axonal degeneration, correlated with islet cell adenomas causing hypoglycemia.
Area of Science:
- * Neuroscience
- * Oncology
- * Endocrinology
Background:
- * SV40 transgenic mice (SV-202) spontaneously develop peripheral neuropathy, pancreatic islet cell adenomas, and hepatocellular carcinomas.
- * The neuropathy's pathogenesis and relationship to tumorigenesis require elucidation.
Purpose of the Study:
- * Characterize the morphology and distribution of neuropathologic lesions in SV-202 mice.
- * Correlate peripheral nerve lesion development with pancreatic islet cell tumorigenesis.
Main Methods:
- * Morphologic and distribution analysis of neuropathologic lesions.
- * Temporal correlation of peripheral nerve lesions with islet cell adenomas.
Main Results:
- * SV-202 mice exhibited generalized peripheral neuropathy characterized by acute axonal degeneration, primarily affecting large myelinated fibers.
- * Neuropathy onset closely correlated with hyperinsulinemia and hypoglycemia from islet cell adenomas.
- * Neuropathy was not directly linked to T-antigen expression in the nervous system.
Conclusions:
- * SV40-induced islet cell adenomas contribute to peripheral neuropathy development in SV-202 mice via metabolic disturbances.
- * This model offers insights into the interplay between endocrine tumors and neurological complications.