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Related Concept Videos

Gross Anatomy of the Liver01:17

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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
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Transjugular liver biopsy.

Michel Ble1, Bogdan Procopet2, Rosa Miquel3

  • 1Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic, IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona), C/ Villarroel 173, Barcelona 08036, Spain.

Clinics in Liver Disease
|December 2, 2014
PubMed
Summary

Transjugular liver biopsy (TJLB) offers a safe and effective alternative to percutaneous liver biopsy, especially for patients with ascites or coagulopathy. This technique provides high-quality tissue samples with minimal complications, aiding in the diagnosis of liver diseases.

Keywords:
Cirrhosis stageHVPGLiver specimenMenghini needleTissue sample qualityTransjugular liver biopsyTru-Cut needleUltrasound guidance

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Area of Science:

  • Hepatology
  • Interventional Radiology
  • Diagnostic Procedures

Background:

  • Liver biopsy remains the gold standard for diagnosing acute and chronic liver diseases.
  • Noninvasive methods for liver disease diagnosis and staging have advanced but have limitations.
  • Percutaneous liver biopsy may be contraindicated in patients with ascites or coagulopathy.

Purpose of the Study:

  • To provide a comprehensive overview of the transjugular liver biopsy (TJLB) technique.
  • To discuss the applicability, indications, contraindications, complications, and diagnostic accuracy of TJLB.
  • To highlight TJLB as a valuable option for liver disease evaluation.

Main Methods:

  • Review of existing literature and clinical experience with TJLB.
  • Description of the TJLB procedure, including patient preparation and execution.
  • Analysis of data regarding the safety, efficacy, and diagnostic yield of TJLB.

Main Results:

  • TJLB is a safe procedure with a low complication rate.
  • It yields high-quality liver specimens suitable for diagnosis.
  • TJLB is particularly useful when percutaneous approaches are contraindicated, such as in cases of ascites or coagulopathy.
  • Diagnostic hemodynamic procedures can be performed concurrently.

Conclusions:

  • Transjugular liver biopsy (TJLB) is a safe and effective method for evaluating liver diseases.
  • It serves as a crucial alternative when percutaneous liver biopsy is not feasible.
  • TJLB offers excellent diagnostic accuracy and can be combined with hemodynamic assessments.