Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

830
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
830
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

376
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
376
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

365
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
365
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

336
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
336
Dosage Interval and Administration Route: Determination Methods01:19

Dosage Interval and Administration Route: Determination Methods

538
A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to...
538
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

374
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
374

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Atypical Skin Presentation of Adult-Onset Still's Disease With Histological Description: A Case Report.

Journal of cutaneous pathology·2026
Same author

Bias in AI models for fetal cardiac screening: the consequences of training predominantly on normal anatomy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2026
Same author

Antibiotic prescription for older patients in end-of-life care: a randomized survey among physicians in Switzerland.

BMC geriatrics·2026
Same author

National survey on aspiration pneumonia in elderly hospitalized or institutionalized patients in France in 2023.

Infectious diseases now·2025
Same author

Prevention of aspiration pneumonia recurrences.

Infectious diseases now·2025
Same author

Discordance in maximum velocities in the middle cerebral arteries of monochorionic twins: beyond twin anemia-polycythemia sequence.

American journal of obstetrics and gynecology·2025

Related Experiment Video

Updated: Apr 20, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.8K

[Subcutaneous antibiotic administration in elderly patients].

V Gassler, J Stirnemann, A Huttner

    Revue Medicale Suisse
    |December 3, 2014
    PubMed
    Summary

    Subcutaneous (SC) antibiotic use, especially ceftriaxone, is common in elderly and palliative patients but lacks robust evidence. More research is needed to confirm its effectiveness and safety compared to other methods.

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Geriatrics

    Context:

    • Subcutaneous (SC) antibiotic administration is frequently used off-label, particularly in geriatric and palliative care settings.
    • SC ceftriaxone is the most common choice due to favorable properties and low local toxicity, with some local approvals.
    • Established routes of administration are often challenging for these patient populations.

    Purpose:

    • To highlight the lack of pharmacologic and clinical data supporting SC antibiotic administration.
    • To emphasize the absence of studies demonstrating non-inferiority compared to other parenteral routes.
    • To advocate for randomized controlled trials assessing the efficacy and tolerability of SC antibiotics.

    Summary:

    • Despite frequent off-label use, especially for ceftriaxone in elderly and palliative patients, robust clinical and pharmacologic data for subcutaneous (SC) antibiotic administration are lacking.

    More Related Videos

    A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
    06:18

    A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

    Published on: March 3, 2023

    2.0K

    Related Experiment Videos

    Last Updated: Apr 20, 2026

    Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
    12:18

    Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

    Published on: February 9, 2011

    23.8K
    A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
    06:18

    A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

    Published on: March 3, 2023

    2.0K
  • Current evidence does not demonstrate the non-inferiority of the SC route compared to other parenteral methods.
  • Local committees have approved SC ceftriaxone based on pharmacological parameters and low toxicity, but clinical validation is needed.

    • Impact:

    • Addresses a critical knowledge gap in the frequent use of SC antibiotics in vulnerable populations.
    • Provides a rationale for conducting rigorous clinical trials to establish evidence-based guidelines.
    • Informs clinical practice and policy regarding the safe and effective use of SC antibiotics in aging patients.