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Updated: Apr 20, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
[Serious adverse events after microbial sealant application in paediatric patients]
P Roy1, A Loubière1, T Vaillant1
1Service pharmacie, centre chirurgical Marie-Lannelongue, 133, avenue de la Résistance, 92350 Le Plessis-Robinson, France.
Background:
Integuseal(®) is a cyanoacrylate-based medical device (IIa class), used in surgery after skin preparation to reduce bacterial contamination. It is not officially contraindicated for children.
Objectives:
To describe a case series of skin lesions in pediatric patients after using Integuseal(®) in cardiac surgery.
Methods:
Case series.
Results:
Between September 2012 and February 2013, 153 pediatric patients were treated by Integuseal(®) to prepare for a cardiac surgery in our center: 5 patients (2%) had serious cutaneous reactions. The average age of patients having had lesions is 16months (the youngest patient being 1month old and the oldest being 5years and 8months old).
Issues:
The risk factor in the development of skin lesion seems to be particularly related to the patient's age and sternal location. Other medical literature reports instances of cyanoacrylate intolerance in a variety of other situations.
Conclusion:
Using Integuseal(®) on children does not appear to be safe.
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