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Whole-brain radiotherapy in patients with brain metastases from melanoma
Macarena de la Fuente1, Kathryn Beal, Richard Carvajal
1Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Aims:
To describe results of melanoma brain metastases (BM) treated with whole-brain radiation (WBRT).
Methods:
Retrospective review of patients with melanoma BM treated with WBRT divided into two groups based on the timing of WBRT (at BM diagnosis or recurrence).
Results:
We identified 61 patients with melanoma BM who received WBRT. For the group treated at diagnosis (n = 39): median overall survival was 3 months; best radiographic response included one partial response, ten stable disease, 18 progressive disease, and ten no follow-up imaging. For the group treated at recurrence (n = 22): median overall survival was 3 months; best radiographic response was three partial response, four stable disease, eight progressive disease, and seven no follow-up imaging.
Conclusion:
WBRT activity was limited; however, its role in symptom palliation is unclear.
