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Clinically significant fatigue after stroke: a longitudinal cohort study.

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Clinically significant fatigue affects a third of stroke survivors one month post-stroke. While most recover, about a third still experience fatigue at 12 months, impacting recovery.

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Clinical Psychology

Background:

  • Fatigue is a common and distressing symptom for stroke survivors.
  • The long-term trajectory of clinically significant fatigue post-stroke remains unclear.

Purpose of the Study:

  • To determine the frequency, severity, and time course of clinically significant fatigue within the first 12 months after stroke onset.
  • To analyze the persistence and resolution of fatigue in the post-stroke period.

Main Methods:

  • Recruited patients with recent acute stroke.
  • Conducted structured interviews at one, six, and 12 months post-stroke to identify clinically significant fatigue.
  • Assessed fatigue severity using the Fatigue Assessment Scale (FAS).

Main Results:

  • One month post-stroke, 33% of patients (43/132) experienced clinically significant fatigue.
  • At 12 months, 21% of patients (18/86) who attended all assessments still had clinically significant fatigue.
  • Among patients assessed at one and six months, 64% maintained their fatigue status, with 15% becoming non-fatigued and 9% becoming fatigued.

Conclusions:

  • Clinically significant fatigue is prevalent in one-third of patients one month after stroke.
  • Approximately two-thirds of fatigued patients recover by six months, with most remaining non-fatigued at 12 months.
  • A significant minority (one-third) continue to experience fatigue at 12 months post-stroke.