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Related Concept Videos

Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

20
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
20
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

5.0K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
5.0K
Asthma I: Introduction01:28

Asthma I: Introduction

16
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
16
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.4K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.4K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.8K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.8K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.8K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.8K

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Related Experiment Video

Updated: Apr 20, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

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Developing and emerging clinical asthma phenotypes.

Pieter-Paul W Hekking1, Elisabeth H Bel1

  • 1The Department of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands.

The Journal of Allergy and Clinical Immunology. in Practice
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Clinicians are exploring new ways to classify asthma phenotypes beyond traditional triggers. Biomarker-based approaches show promise for targeted therapies and improved asthma outcomes.

Keywords:
Adult-onset asthmaAir pollution-induced asthmaAsthmaCigarette smoke-induced asthmaCough-variant asthmaEosinophilic asthmaExacerbation-prone asthmaExercise-induced asthmaNeutrophilic asthmaObesityOccupational asthmaPersistent airflow limitationPhenotypesReview

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Related Experiment Videos

Last Updated: Apr 20, 2026

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
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Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Immunology

Background:

  • Asthma classification has historically relied on triggers, disease course, and prognosis.
  • Established phenotypes include allergic, nonallergic, infectious, and aspirin-exacerbated asthma.
  • The current focus is on developing and emerging clinical asthma phenotypes.

Purpose of the Study:

  • To review developing and emerging clinical asthma phenotypes.
  • To explore phenotypes associated with environmental exposures, specific symptoms, and biomarkers.
  • To highlight the potential of biomarker-based phenotyping for personalized asthma treatment.

Main Methods:

  • Review of existing literature on asthma phenotyping.
  • Categorization of emerging phenotypes based on environmental exposures.
  • Categorization of emerging phenotypes based on clinical characteristics (e.g., cough, obesity, adult onset).
  • Exploration of biomarker-based phenotyping strategies.

Main Results:

  • Emerging phenotypes are linked to environmental factors like pollution and occupational agents.
  • Phenotypes associated with cough, obesity, and adult-onset asthma are being identified.
  • Biomarker-based phenotyping offers a promising avenue for understanding underlying disease mechanisms.

Conclusions:

  • Asthma phenotyping is evolving beyond traditional classifications.
  • Environmental exposures and clinical characteristics define new phenotype categories.
  • Biomarker-driven phenotyping holds significant potential for advancing targeted asthma therapies and improving patient outcomes.