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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.8K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
5.0K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.8K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.8K
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

22
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
22
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

2.0K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Related Experiment Video

Updated: Apr 20, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Allergic bronchopulmonary aspergillosis.

Paul A Greenberger1, Robert K Bush2, Jeffrey G Demain3

  • 1Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.

The Journal of Allergy and Clinical Immunology. in Practice
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Disagreement exists on diagnosing and treating allergic bronchopulmonary aspergillosis (ABPA). Surveyed experts show varied IgE thresholds, suggesting ABPA may be underdiagnosed, with oral steroids being a common treatment.

Keywords:
AllergicAspergillosisAsthmaAzoleBronchopulmonarIgEMycosis

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Area of Science:

  • Pulmonology
  • Allergy and Immunology
  • Medical Practice Survey

Background:

  • Allergic bronchopulmonary aspergillosis (ABPA) lacks standardized diagnostic criteria and treatment guidelines.
  • Variability in clinical practice may impact patient outcomes and disease recognition.

Purpose of the Study:

  • To assess current diagnostic criteria and treatment approaches for ABPA among specialists.
  • To compare physician practices with existing published recommendations.
  • To identify potential areas of underdiagnosis in ABPA.

Main Methods:

  • A literature review was conducted for relevant reports on ABPA diagnosis and treatment.
  • An electronic survey was distributed to members and fellows of the American Academy of Allergy, Asthma, & Immunology (AAAAI).
  • The survey collected data on diagnostic criteria, patient numbers, and treatment strategies for ABPA.

Main Results:

  • 48% of surveyed AAAAI members had treated at least one ABPA patient in the prior year.
  • Significant variation exists in the threshold for total serum IgE used for ABPA diagnosis (≥417 kU/L vs. ≥1000 kU/L).
  • Oral corticosteroids are recommended for 97.1% of patients; combination therapy (oral steroids, inhaled corticosteroids, antifungals) is used in 41.2%.

Conclusions:

  • The study highlights significant discordance in diagnostic criteria and treatment practices for ABPA.
  • Varied IgE thresholds suggest potential underdiagnosis of ABPA.
  • Current treatment predominantly involves oral corticosteroids, with azoles as adjunctive therapy; omalizumab use is limited.