Related Experiment Video
Updated: Apr 20, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Blood PGC-1α Concentration Predicts Myocardial Salvage and Ventricular Remodeling After ST-segment Elevation Acute
Óscar Fabregat-Andrés1, Francisco Ridocci-Soriano2, Jordi Estornell-Erill3
1Servicio de Cardiología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain; Fundación de Investigación, Hospital General de Valencia, Valencia, Spain.
Insights
Detecting Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) in blood after myocardial infarction predicts better heart recovery. Higher PGC-1α levels indicate greater myocardial salvage and less ventricular remodeling post-infarction.
Area of Science:
- Cardiology
- Biochemistry
- Molecular Biology
Background:
- Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a key metabolic regulator.
- PGC-1α is induced during ischemia and has shown cardioprotective effects in animal models.
- Assessing PGC-1α activity in ST-segment elevation acute myocardial infarction (STEMI) patients is feasible.
Purpose of the Study:
- To evaluate the predictive value of blood PGC-1α levels for myocardial necrosis extent.
- To assess the association of PGC-1α levels with ventricular remodeling after infarction.
- To determine the relationship between PGC-1α expression and myocardial salvage in STEMI patients.
Main Methods:
- Prospective study of 31 first-time anterior STEMI patients with successful reperfusion.
- PGC-1α expression measured in peripheral blood on admission and at 72 hours.
- Cardiac magnetic resonance imaging (MRI) used to assess edema, necrosis, infarct size, and ventricular remodeling at 6 months.
Main Results:
- Patients with detectable baseline PGC-1α showed significantly greater myocardial salvage (18.3% vs 4.5%, P=.04).
- Induction of PGC-1α at 72 hours correlated with increased ventricular remodeling (29.7% vs 1.2% change in LVEDV, P=.04).
Conclusions:
- Baseline PGC-1α expression is linked to greater myocardial salvage after acute myocardial infarction.
- An attenuated systemic PGC-1α response predicts less ventricular remodeling.
- Blood PGC-1α levels may serve as a biomarker for predicting outcomes post-STEMI.
Introduction And Objectives:
Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a metabolic regulator induced during ischemia that prevents cardiac remodeling in animal models. The activity of PGC-1α can be estimated in patients with ST-segment elevation acute myocardial infarction. The aim of the present study was to evaluate the value of blood PGC-1α levels in predicting the extent of necrosis and ventricular remodeling after infarction.
Methods:
In this prospective study of 31 patients with a first myocardial infarction in an anterior location and successful reperfusion, PGC-1α expression in peripheral blood on admission and at 72 hours was correlated with myocardial injury, ventricular volume, and systolic function at 6 months. Edema and myocardial necrosis were estimated using cardiac magnetic resonance imaging during the first week. At 6 months, infarct size and ventricular remodeling, defined as an increase > 10% of the left ventricular end-diastolic volume, was evaluated by follow-up magnetic resonance imaging. Myocardial salvage was defined as the difference between the edema and necrosis areas.
Results:
Greater myocardial salvage was seen in patients with detectable PGC-1α levels at admission (mean [standard deviation (SD)], 18.3% [5.3%] vs 4.5% [3.9%]; P = .04). Induction of PGC-1α at 72 hours correlated with greater ventricular remodeling (change in left ventricular end-diastolic volume at 6 months, 29.7% [11.2%] vs 1.2% [5.8%]; P = .04).
Conclusions:
Baseline PGC-1α expression and an attenuated systemic response after acute myocardial infarction are associated with greater myocardial salvage and predict less ventricular remodeling.
More Related Videos
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
05:26Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Acute Coronary Syndrome I: Introduction