Fine needle aspiration cytology of hepatocellular carcinoma manifested as bone metastasis

Symptomatic skeletal metastasis in hepatocellular carcinoma is rare. We have presented two cases of expansile, lytic lesions involving the distal radius and sacrococcyx, respectively. Initially, diagnosis was made by fine needle aspiration cytology, complemented by positive alpha-fetoprotein immunoperoxidase staining in one and ultrastructural evaluation in both.