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Risk factors of cerebral microbleeds in strictly deep or lobar brain regions differed

Changqing Zhang1, Zixiao Li1, Yilong Wang1

  • 1Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|December 3, 2014
PubMed
Abstract

Insights

Risk factors for cerebral microbleeds (MBs) in deep versus lobar brain regions show modest differences. Deep MBs are linked to higher blood pressure, while lobar MBs are associated with older age.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Cerebral microbleeds (MBs) are detectable via T2*-weighted MRI.
  • Risk factors for MBs in different brain regions require further investigation.

Purpose of the Study:

  • To investigate distinct risk factors for MBs in strictly deep versus lobar brain regions.

Main Methods:

  • Analysis of 696 acute ischemic stroke patients.
  • Evaluation of MBs, lacunes, leukoaraiosis (LA), and stroke subtypes.
  • Multivariable logistic regression to identify risk factors.

Main Results:

  • 162 patients (23.3%) had MBs; 62 deep, 49 lobar.
  • MBs correlated with lacunes and severe LA.
  • Deep MBs associated with higher mean arterial pressure; lobar MBs with older age.

Conclusions:

  • Risk factors for deep and lobar MBs differ slightly.
  • These differences may reflect varied vascular pathologies.
Keywords:
Microbleedscerebral small vessel diseasesmagnetic resonance imagingrisk factors

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