Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

16.2K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
16.2K
Blood Transfusion01:15

Blood Transfusion

3.2K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
3.2K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.8K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.8K
Rh Blood Group01:19

Rh Blood Group

4.6K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
4.6K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

88.7K
Overview
88.7K
The ABO Blood Group01:12

The ABO Blood Group

8.7K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Compact Dual Ion Composition Experiment (CoDICE) for the IMAP Mission.

Space science reviews·2025
Same author

Practice Patterns of Canadian Neurosurgeons in Laparoscopic-Assisted Placement of Ventriculoperitoneal Shunts.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2025
Same author

A randomised controlled feasibility trial of a clinical protocol to manage hypotension during major non-cardiac surgery.

Anaesthesia·2023
Same author

A superconducting switch actuated by injection of high-energy electrons.

Nature communications·2021
Same author

Estimation of External Contamination and Exposure Rates Due to Fission Product Release.

Health physics·2020
Same author

Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study.

British journal of anaesthesia·2019

Related Experiment Video

Updated: Apr 20, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

18.5K

Red cell transfusion and the immune system.

S Hart1, C M Cserti-Gazdewich, S A McCluskey

  • 1Department of Anaesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

Anaesthesia
|December 3, 2014
PubMed
Summary

Red blood cell transfusions have significant immunological effects, including underappreciated immune modulation. Clinicians must weigh these immunological risks against transfusion benefits for safe patient care.

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

2.0K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.7K

Related Experiment Videos

Last Updated: Apr 20, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

18.5K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

2.0K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.7K

Area of Science:

  • Immunology
  • Transfusion Medicine
  • Hematology

Background:

  • Red blood cell transfusion is a critical medical intervention.
  • Understanding its immunological impact is vital for safe and effective use.
  • Current risk-benefit assessments may underemphasize certain immunological consequences.

Purpose of the Study:

  • To review the immunological consequences of red blood cell transfusion.
  • To highlight underappreciated immunological insults.
  • To inform clinical risk-benefit considerations.

Main Methods:

  • Literature review of immunological effects of red blood cell transfusion.
  • Analysis of emerging evidence on transfusion-related immunomodulation.
  • Synthesis of findings to guide clinical practice.

Main Results:

  • Transfusion involves significant immunological exposure.
  • Known risks include major incompatibility and acute lung injury.
  • Transfusion-related immunomodulation is a significant, often underappreciated, consequence.

Conclusions:

  • Red blood cell transfusions are immunological events with multifaceted consequences.
  • A comprehensive understanding of immunological risks is essential.
  • Balancing transfusion benefits with immunological risks is crucial for patient safety.