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Alcohol-related morbidity and mortality within siblings
Grethe Søndergaard1, Merete Osler, Anne-Marie Nybo Andersen
1Research Centre for Prevention and Health, Glostrup University Hospital, Nordre Ringvej 57, Building 84/85, DK-2600, Glostrup, Denmark.
Addiction (Abingdon, England)
|December 3, 2014
Summary
Lower educational status is linked to increased alcohol-related health issues, particularly in younger individuals. Familial factors play a minor role in this association, suggesting socioeconomic influences are more significant.
Area of Science:
- Public Health
- Epidemiology
- Sociology
Background:
- Socioeconomic status, particularly educational attainment, is a known determinant of health outcomes.
- Alcohol-related morbidity and mortality represent a significant public health burden.
- Understanding the interplay between education, familial factors, and alcohol-related harm is crucial for targeted interventions.
Purpose of the Study:
- To investigate the association between educational status and alcohol-related somatic and non-somatic morbidity and mortality.
- To compare these associations among full siblings versus non-related individuals to disentangle familial influences.
Main Methods:
- A large cohort study of approximately 1.4 million full siblings in Denmark, born between 1950 and 1979.
- Follow-up from age 28-58 years, with censoring for alcohol-related hospitalizations and mortality.
- Cox regression analyses were employed to estimate hazard rate ratios (HR) and compare cohort and inter-sibling analyses.
Main Results:
- A lower educational status was significantly associated with a higher rate of alcohol-related outcomes, especially in younger individuals (28-37 years) and those born 1970-79.
- Associations attenuated slightly in inter-sibling analyses compared to cohort analyses, indicating a small contribution of familial factors.
- For instance, females with basic school education born 1970-79 showed elevated HRs for non-somatic outcomes (cohort: 4.05, sibling: 2.66) and somatic outcomes (cohort: 3.47, sibling: 3.36).
- Associations were generally stronger in females than males for non-somatic outcomes.
Conclusions:
- The association between educational status and alcohol-related morbidity and mortality is influenced by familial factors to a limited extent.
- Socioeconomic disparities in alcohol-related harm are primarily driven by factors beyond shared genetics and upbringing.
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