Related Experiment Video

Updated: Apr 20, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.7K

GD2-targeted immunotherapy and radioimmunotherapy

Konstantin Dobrenkov1, Nai-Kong V Cheung1

  • 1Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY.

Seminars in Oncology
|December 3, 2014
PubMed

Insights

Ganglioside GD2 is a target for cancer immunotherapy. Anti-GD2 antibodies are effective in treating neuroblastoma and other cancers, with new therapies rapidly advancing.

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Ganglioside GD2 is a surface antigen prevalent in various pediatric and adult cancers.
  • Its limited expression in normal tissues makes it a safe target for immunotherapies.
  • Anti-GD2 antibody therapy is a standard treatment for high-risk metastatic neuroblastoma.

Purpose of the Study:

  • To review past and present immunotherapy trials targeting Ganglioside GD2.
  • To highlight key findings and lessons learned from these trials.
  • To discuss future directions for GD2-targeted therapies.

Main Methods:

  • Review of existing clinical trial data for GD2-targeted immunotherapies.
  • Analysis of treatment outcomes and safety profiles.
  • Synthesis of information on novel therapeutic combinations.

Main Results:

  • GD2-targeted therapies have shown efficacy, particularly in neuroblastoma.
  • The safety profile of GD2 targeting is favorable due to restricted normal tissue expression.
  • Emerging therapies involve combinations of antibodies, cytokines, and cellular products.

Conclusions:

  • Ganglioside GD2 is a validated and promising target for cancer immunotherapy.
  • Ongoing research is focused on novel combinations and advanced therapeutic strategies.
  • Further clinical trials are essential to optimize GD2-targeted treatment regimens.

More Related Videos

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

22.2K
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts11:15

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

8.6K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.4K