An algorithmic approach to multimodality midfacial rejuvenation using a new classification system for midfacial aging
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Updated: Apr 20, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Andrew A Jacono1, Joseph J Rousso2
1Facial Plastic & Reconstructive Surgery, North Shore University Hospital, Manhasset, NY, USA; Division of Facial Plastic & Reconstructive Surgery, Department of Otolaryngology/Head and Neck Surgery, New York Eye and Ear Infirmary, New York, NY, USA; New York Center for Facial Plastic & Laser Surgery, New York, NY, USA; New York Center for Facial Plastic & Laser Surgery, Great Neck, NY, USA.
Abstract:
Midfacial aging is the result of the complex interplay between the osseous skeleton, facial retaining ligaments, soft tissues envelope, facial fat compartments, and the overlying skin elasticity. As a result of the many anatomic components involved in midfacial aging, the authors proposed a classification system based on distinct anatomic factors to direct surgical treatment. Evidence based data suggest that midface rejuvenation often requires a multimodality approach to obtain desired results, especially in patients with more advanced aging and poor tissue elasticity, or those with hypoplastic midfacial skeletal structure.
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