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Updated: Apr 20, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
An algorithmic approach to multimodality midfacial rejuvenation using a new classification system for midfacial
Andrew A Jacono1, Joseph J Rousso2
1Facial Plastic & Reconstructive Surgery, North Shore University Hospital, Manhasset, NY, USA; Division of Facial Plastic & Reconstructive Surgery, Department of Otolaryngology/Head and Neck Surgery, New York Eye and Ear Infirmary, New York, NY, USA; New York Center for Facial Plastic & Laser Surgery, New York, NY, USA; New York Center for Facial Plastic & Laser Surgery, Great Neck, NY, USA.
Midfacial aging involves bone, ligaments, fat, and skin. A new classification system guides surgical treatment for midface rejuvenation, often requiring multiple approaches for optimal results.
Area of Science:
- Plastic Surgery
- Anatomy
- Gerontology
Background:
- Midfacial aging results from complex interactions of skeletal, ligamentous, soft tissue, and skin components.
- Aging affects facial fat compartments and skin elasticity, contributing to a aged appearance.
Purpose of the Study:
- To propose a classification system for midfacial aging based on distinct anatomic factors.
- To guide surgical treatment strategies for midface rejuvenation.
Main Methods:
- Review of anatomic factors contributing to midfacial aging.
- Development of a classification system based on these factors.
Main Results:
- A classification system was proposed to categorize midfacial aging.
- The system aims to direct tailored surgical interventions.
Conclusions:
- Midface rejuvenation often necessitates a multimodality approach.
- Treatment strategies should consider patient-specific factors like aging severity, tissue elasticity, and skeletal structure.
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