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Related Concept Videos

Pneumothorax-II01:27

Pneumothorax-II

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Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
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Pleura of the Lungs01:13

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Pleural Effusion II: Symptoms and Management01:28

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Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
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Endoscopic Studies I: Bronchoscopy and Thoracoscopy01:30

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Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
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Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
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Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

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The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
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Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

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Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
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Related Experiment Video

Updated: Apr 20, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer
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Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

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Extrapleural pneumonectomy for pleural malignancies.

Andrea S Wolf1, Raja M Flores1

  • 1Department of Thoracic Surgery, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1023, New York, NY 10029, USA.

Thoracic Surgery Clinics
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Extrapleural pneumonectomy (EPP) can treat certain non-small cell lung cancers (NSCLC) with malignant pleural effusion. Careful patient selection and experienced surgical teams are crucial for this radical procedure.

Keywords:
Extrapleural pneumonectomyMalignant pleural effusionNonsmall cell lung cancerPleural carcinomatosis

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Area of Science:

  • Thoracic Surgery
  • Surgical Oncology
  • Pulmonary Medicine

Background:

  • Extrapleural pneumonectomy (EPP) was initially for tuberculosis and mesothelioma.
  • EPP is now considered for other malignancies with pleural spread, including thymoma and non-small cell lung cancer (NSCLC).

Purpose of the Study:

  • To evaluate the role of EPP in managing NSCLC with malignant pleural effusion.
  • To identify patient selection criteria and procedural considerations for EPP in NSCLC.

Main Methods:

  • Review of literature and clinical guidelines regarding EPP for pleural malignancies.
  • Analysis of patient characteristics, including staging, metastatic status, and cardiopulmonary reserve.
  • Emphasis on the importance of experienced surgical teams and centers.

Main Results:

  • EPP may be an option for Stage IV NSCLC with malignant pleural effusion after induction chemotherapy.
  • Key selection criteria include absence of mediastinal nodal or distant metastases and adequate cardiopulmonary reserve.
  • Minimizing morbidity and mortality requires experienced teams at specialized centers.

Conclusions:

  • EPP can be a treatment option for select NSCLC patients with malignant pleural effusion.
  • Further prospective studies are necessary to define the optimal role of EPP in the multimodality treatment of pleural malignancies like NSCLC.