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Infectious Diseases and Their Occurrence01:28

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Endocarditis I: Introduction01:25

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Related Experiment Video

Updated: Apr 20, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
06:34

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Published on: July 11, 2016

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Rarely seen infections.

Mohamed Amer1, Amin Amer1

  • 1Department of Dermatology and Venereology, Medical School, Zagazig University, Sharkiyah, Egypt.

Clinics in Dermatology
|December 3, 2014
PubMed
Summary

Facial cutaneous leishmaniasis (CL) and atypical mycobacterial infections are often misdiagnosed due to their rarity in some regions. Early diagnosis and treatment are crucial for these rare facial infections.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Medical Microbiology

Background:

  • Rare facial infections like cutaneous leishmaniasis (CL) and atypical mycobacterial infections pose diagnostic challenges for clinicians unfamiliar with their presentation.
  • CL, a protozoan infection transmitted by sand flies, exists in Old World and New World forms, with varying prevalence globally.
  • Atypical mycobacterial infections have gained attention due to advancements in diagnostic methods and increased prevalence in immunocompromised individuals, particularly those with HIV.

Purpose of the Study:

  • To highlight the diagnostic challenges associated with rare facial infections, specifically cutaneous leishmaniasis and atypical mycobacterial infections.
  • To inform medical practitioners about the varying geographical distribution and presentation of cutaneous leishmaniasis.
  • To discuss the impact of diagnostic advancements on the understanding and management of atypical mycobacterial infections.

Related Experiment Videos

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Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
06:34

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Published on: July 11, 2016

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Main Methods:

  • Review of medical literature on rare facial infections, focusing on cutaneous leishmaniasis and atypical mycobacterial infections.
  • Discussion of diagnostic criteria and epidemiological patterns of these infections.
  • Mention of advancements in mycobacteriology, including rapid radiometric detection systems and antimicrobial susceptibility testing.

Main Results:

  • Cutaneous leishmaniasis is geographically specific, being common in Central/South America (New World) and parts of Africa/Asia/Europe (Old World), but rare in the United States, leading to potential misdiagnosis.
  • Rapid radiometric detection systems have significantly improved the diagnosis and antimicrobial susceptibility testing of mycobacteria.
  • Atypical mycobacterial infections are increasingly recognized, especially in HIV-infected patients, due to improved diagnostics and disease prevalence.

Conclusions:

  • Increased awareness and understanding of geographically specific infections like CL are essential for accurate diagnosis.
  • Advances in mycobacterial diagnostics have improved the identification and management of atypical mycobacterial infections.
  • Prompt diagnosis and appropriate treatment are critical for managing rare facial infections to prevent complications.